McMurray Office (724) 941-0707 | Irwin Office (724) 382-5626


Legacy Medical Centers offers various types of regenerative medicine options depending on the patients conditions and needs. We offer a compbination of PRP (Platelet Rich Plasma), Amniotic Fluid, Bone Marrow Aspirate Stem Cells, Hyperbaric Oxygen Chambers, Class IV Lasers and Neutraceuticals.

Why use bone marrow aspirate in stem cell therapy?
Bone marrow’s progenitor stem cells are extremely well suited for regenerating cartilage, ligaments and tendons. It can be used as a direct application (in-office-injection) or as an adjunct in surgery to aid in the regeneration and healing of injured tissue. This technique is point-of-care, the cells are not manipulated and are utilized as treatment at the same time of the harvest. The harvest is from the posterior (back) portion of the pelvic bone. We use local anesthetic and patients rarely complain of any discomfort following the harvest. and the marrow taken grows back!

Evidence-Based Applications!
There continues to be expanding indications for the use of bone marrow derived adult stem cells. We are using them for cartilage damage, arthritis, rotator cuff tears, tendon tears and hip labral injuries.

Why don’t we use fat stem cells as a main compononent in our protocol?
The harvesting of cells from fat has carried over into orthopedic applications from plastic surgery applications. While they are a great source for plastic surgery, and there are large numbers of mesenchymal stem cells found in fat, bone marrow cells are better suited for orthopedic applications as they contain many components that fat stem cells simply do not have. There are many clinics promoting fat stem cells for joint regeneration but in 10+ head to head clinical studies, bone marrow derived stem cells had better results in every study. There is not a single study out there that shows fat stem cells as a better option over bone marrow-derived stem cells.

Improvement from stem cell Injections?
We’ve seen significant decreases in pain as quickly as 5-6 days, but the whole event may not be optimized for 3-4 months. A recent study that was published utilized similar treatments that we use at Legacy Medical Centers. Bone marrow was aspirated/concentrated using a standardized technique. Patients received a single joint injection (knee, ankle, shoulder, hip) of BMC, with follow-up injection of PRP at 8 weeks. The median patient satisfaction at approximately 5 months was  9.0/10 at a with 91.7% indicated that they would repeat the procedure and 94% said that they would recommend the procedure to a friend. The Conclusion was an Intra-articular injection of BMC, followed by a PRP injection, can provide short-term benefits in moderate-to-severe osteoarthritis. Click here to see the full study:

This study was conducted from 2012 to 2013 but just published in 2016. At Legacy Medical Centers we are using the latest in technology to provide higher cell counts along with additional modalities to assist in our patients quest to get back to enjoying life without the pain.

How long would you estimate this treatment would be effective? 

This is an evolving field; and as such, it is still considered investigational from an insurance standpoint. However, the cells will help to regenerate new tissue in the proper environment and the science suggests that the tissue may be as robust as normal tissue. People who have had shoulder surgery and cartilage surgery with stem cells applied recovered quicker than those with the same surgery without stem cells.

Why use Amniotic Fluid?
Amniotic Fluid is a human amniotic tissue allograft that contains multipotent cells, growth factors and a tissue scaffold. The anti-inflammatory and regenerative elements help treat painful conditions such as joint and soft tissue inflammation, arthritis and damaged cartilage. This non-operative procedure is typically administered in the doctors office.

What is Amniotic Tissue?
Amniotic tissue is the inner layer of the placenta that surrounds the fetus during pregnancy. This amniotic tissue and fluid contains a high density of cells as well as other biological growth factors that have profound regenerative properties. The Nanofactor™ human amniotic tissue allograft is donated to a tissue bank by healthy mothers at the time of a live cesarean childbirth

Amniotic Fluid
Amniotic Fluid is a human amniotic tissue allograft that contains multipotent cells, growth factors and a tissue scaffold. The anti-inflammatory and regenerative elements help treat painful conditions such as joint inflammation, arthritis and damaged cartilage.

What are the benefits?
Amniotic tissue, by its very nature, is a universal transplant graft that is not subject to rejection (immune reaction). Amniotic is nutrient rich, very potent and able to stimulate the body’s natural healing process. The multipotent cells contained in the graft are capable of differentiating into numerous types of tissue such as cartilage, bone, tendon, ligament or muscle. Growth factors, proteins, cytokines and other elements in the graft are also thought to be beneficial for healing, tissue regeneration and pain reduction.

Amniotic Fluid contains:amnio-man

  • Growth Factors
  • Cytokines
  • Collagen
  • Fibrinogen
  • Hyaluronic Acid
  • Amino Acids
  • Cells



One key characteristic of amniotic tissue is its anti-inflammatory properties. Inflammation is commonly referred to as tenderness, swelling or irritation of the joint and is often the source of pain. Many times, simply by reducing the inflammation, pain can go away. In addition, amniotic tissue has anti-adhesive and antimicrobial properties. Anti-adhesive properties can be especially helpful in reducing scarring for quicker healing while the anti-microbial properties promote germ-fighting capabilities which can be beneficial for wound healing. Amniotic tissue is also immuno-privileged, an important property for a tissue graft. Immuno-privileged means there is virtually no chance that your body will reject the graft. As part of the graft preparation process, the outer layer of the placenta, the chorion layer, is removed. The chorion layer contains the mothers’ antigens (HLA) that would normally elicit a foreign body (immune) reaction. By removing this layer, the main risk factor for graft rejection is eliminated.

How is Amniotic different from other grafts?

Your cells and tissues can age with time just like everything else. Amniotic tissue, it is essentially unadulterated by the effects of time. For example, a graft taken from a 46 year old person is almost 17,000 days old. In comparison, the amniotic graft we utilize is only as old as the normal labor term, about 270 days old. Other popular therapies rely on taking the patients own cells and re-injecting them. Amniotic is harvested from a healthy mother, usually between 18-45 years old, and comes from placental tissue and fluid that is harvested during birth.

How does Amniotic provide relief?
The source and type of pain can be complex and varies by joint. Pain may be caused by mechanical symptom, fluid pressure in the joint, trauma, loss of cartilage or inflammation of the tissues in the affected area. Amniotic is engineered to augment the body’s natural healing response by adding in the regenerative biological elements found in amniotic tissue. The anti-inflammatory properties found in amniotic can reduce swelling and inflammation as well as speed up the body’s healing process. The possibility of tissue regeneration at the site of injury may also provide additional relief. Since biological healing works through an inflammatory process, there may be some minor soreness or pain immediately after receiving the injection. Dramatic pain relief may happen as quickly as a few days after injection and for some patients, symptom improvement may occur in a matter of weeks.